Focus
CARDIOVASCULAR RESEARCH
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
The Coronary Artery Disease (C4D) Genetics Consortium
Nature Genetics (2011)
OUTCOME RESEARCH
Association of socioeconomic status with breslow thickness and disease-free and overall survival in stage I-II primary cutaneous melanoma
Mandalà M, Imberti GL, Piazzalunga D, Belfiglio M, Lucisano G, Labianca R, Marchesi L, Merelli B, Robone S, Poletti P, Milesi L, Tondini C.
Mayo Clin Proc. 2011 Feb;86(2):113-9.
CELLULAR SIGNALING
Mono-ADP-ribosylation of the G-protein βγ dimer is modulated by hormones and inhibited by ARF6
Further understanding of the mechanisms that regulate endogenous ADP-ribosylation of the Gb subunit: a novel role for Arf6 in hormone regulation of Gb subunit mono-ADP-ribosylation.
CHRONIC KIDNEY DISEASE
Sexual dysfunction and chronic kidney disease
Prevalence and Correlates of Self-Reported Sexual Dysfunction in CKD: A Meta-analysis of Observational Studies.
Treatment Options for Sexual Dysfunction in Patients with Chronic Kidney Disease: A Systematic Review of Randomized Controlled Trials.
CHOLESTEROL AND ATHEROSCLEROSIS
Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis
Lo Sasso G, Murzilli S, Salvatore L, D'Errico I, Petruzzelli M, Conca P, Jiang ZY, Calabresi L, Parini P, Moschetta A.
Cell Metabolism. 2010 4 August;12(2):187-193
PAIN MANAGEMENT
Impact of setting of care on pain management in patients with cancer: a multicentre cross-sectional study
Sichetti D, Bandieri E, Romero M, Di Biagio K, Luppi M, Belfiglio M, Tognoni G, Ripamonti CI; for ECAD Working Group.
Ann Oncol. 2010 Mar 31. [Epub ahead of print]
GASTROENTEROLOGY
The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors
Modica S, Gofflot F, Murzilli S, D'Orazio A, Salvatore L, Pellegrini F, Nicolucci A, Tognoni G, Copetti M, Valanzano R, Veschi S, Mariani-Costantini R, Palasciano G, Schoonjans K, Auwerx J, Moschetta A.
Gastroenterology. 2010 Feb;138(2):636-48
MOLECULAR MEDICINE
Induction of Prostacyclin by Steady Laminar Shear Stress Suppresses Tumor Necrosis Factor-{alpha} Biosynthesis via Heme Oxygenase-1 in Human Endothelial Cells
Di Francesco L, Totani L, Dovizio M, Piccoli A, Di Francesco A, Salvatore T, Pandolfi A, Evangelista V, Dercho RA, Seta F, Patrignani P.
Circ Res. 2009 Feb 27;104(4):506-13
CLINICAL TRIAL
Valsartan for Prevention of Recurrent Atrial Fibrillation
The GISSI-AF Investigators
N Engl J Med. 2009 Apr 16;360(16):1606-17
CANCER RESEARCH
Nuclear Bile Acid Receptor FXR Protects against Intestinal Tumorigenesis
Salvatore Modica, Stefania Murzilli, Lorena Salvatore, Daniel R. Schmidt, Antonio Moschetta.
Cancer Res 2008 68: 9589-9594
